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Complementary Health Practice Review
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Homocysteine: More Lethal Than Cholesterol?

Melinda E. Hann, RN, BSN, MSN

Russellville, KY

Does homocysteine play a role in the blockage of arteries? If it does, what can be done to rid our bodies of homocysteine? Is homocysteine more lethal than cholesterol ? A meta-analysis of 5-study outcomes is presented for the purpose of describing intervention effectiveness for folate, vitamin B12, and vitamin B6 on plasma homocysteine concentrations. The differences in measurement techniques and study designs preclude direct, quantitative comparisons between studies. However, the 5-study outcomes reviewed for the correlation of vitamin status and homocysteine plasma level, show that there are inverse associations between homocysteine plasma levels and folate, vitamin B12, and vitamin B6 plasma levels and that elevated plasma homocysteine levels can be reduced by increasing the dietary and/or supplemental intake of these three B vitamins. A greater heart disease risk has been linked to people with higher plasma levels of homocysteine, and this may be more lethal than cholesterol.

Complementary Health Practice Review, Vol. 3, No. 3, 177-184 (1997)
DOI: 10.1177/153321019700300305


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